Interrelationship between Chronic Kidney Disease and Risk of Cardiovascular Diseases

Author(s): German T. Hernandez, Michael Sippel, Debabrata Mukherjee.

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry

Volume 11 , Issue 1 , 2013

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Abstract:

An estimated 11% of the U.S. population has chronic kidney disease (CKD). Cardiovascular morbidity and mortality remain high among individuals with CKD and the higher mortality from cardiovascular disease persists even after adjusting for most of the traditional risk factors, suggesting the possible contributions of uremia-related, nontraditional risk factors. This has led to the current understanding that the pathophysiology of cardiovascular disease in CKD involves a complex interplay of both the traditional as well as nontraditional, uremia-related risk factors. Given the high cardiovascular morbidity and mortality, patients with CKD should be a target for aggressive cardiovascular risk reduction.

Keywords: Acute coronary syndrome, anemia, cardiovascular disease, chronic kidney disease, dialysis, dyslipidemia, glomerular filtration rate, hypertension, outcomes, uremia, secondary prevention

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Article Details

VOLUME: 11
ISSUE: 1
Year: 2013
Page: [38 - 43]
Pages: 6
DOI: 10.2174/1871525711311010007

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