Synthesis of a Common Tetrasaccharide Repeating Unit of the O-antigen of Enteroinvasive Escherichia coli O143 and Shigella boydii Type 81

Author(s): Abhishek Santra, Anup Kumar Misra.

Journal Name: Current Organic Synthesis

Volume 10 , Issue 1 , 2013

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Abstract:

A concise chemical synthesis of the common tetrasaccharide corresponding to the O-antigen of enteroinvasive Escherichia coli O143 and Shigella boydii type 8 has been achieved in excellent yield. Application of [2+2] block glycosylation and late stage oxidation of primary hydroxyl groups to the carboxylic groups are notable features in the synthetic strategy.

Keywords: Escherichia coli, Shigella boydii, O-antigen, tetrasaccharide, dysentery

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Article Details

VOLUME: 10
ISSUE: 1
Year: 2013
Page: [178 - 182]
Pages: 5
DOI: 10.2174/1570179411310010010

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