A concise chemical synthesis of the common tetrasaccharide corresponding to the O-antigen of enteroinvasive Escherichia
coli O143 and Shigella boydii type 8 has been achieved in excellent yield. Application of [2+2] block glycosylation and late stage
oxidation of primary hydroxyl groups to the carboxylic groups are notable features in the synthetic strategy.
Keywords: Escherichia coli, Shigella boydii, O-antigen, tetrasaccharide, dysentery
Rights & PermissionsPrintExport