ZnO Nanoparticles-Catalyzed Cyclocondensation Reaction of Arylmethylidenepyruvic Acids with 6-Aminouracils

Author(s): Shahrzad Abdolmohammadi.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 16 , Issue 1 , 2013

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Abstract:

A new, efficient, and solvent-free cyclocondensation reaction of arylmethylidenepyruvic acids with 6- aminouracils is presented that uses a catalytic amount of ZnO nanoparticles (ZnO Nps) as a recyclable catalyst at 70 °C. This protocol has the advantages of high yields (91-98%), easy work-up, very short reaction time (2 h), and using environmentally friendly procedure.

Keywords: Cyclocondensation, heterogeneous catalyst, solvent-free, ZnO nanoparticles, recyclable catalyst, metal oxide, solvent-free.

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Article Details

VOLUME: 16
ISSUE: 1
Year: 2013
Page: [32 - 36]
Pages: 5
DOI: 10.2174/1386207311316010005

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