In order to achieve high bioactivity, low systemic side effects and prevention of high critical hypoglycaemic
conditions of antidiabetic drugs in the treatment of diabetes mellitus, sustained and controlled delivery system is crucial.
In this study, a three-dimensional (3-D) porous scaffold formulation was developed with the ability to release antidiabetic
drugs in a controlled fashion. The gliclazide (GLZ), was successfully incorporated into prefabricated 3-D porous matrix
chitosan scaffolds using a freeze-drying method. Porosity, swelling, water absorption and drug entrapment efficiency was
increased after the addition of PEG 4000. The release kinetics of GLZ from two different (2% and 3%) chitosan scaffold
formulations investigated showed sustained and controlled delivery of GLZ. The GLZ release is strongly dependent upon
the physical and chemical properties of the chitosan and PEG 4000. Scaffold with 3% chitosan discharge GLZ rapidly
with a high initial burst release while scaffold with 2% chitosan can extend the release of GLZ to longer than 2 weeks
with a low initial burst release. Compared to chitosan alone, the PEG 4000 incorporated on a 3-D scaffold had significantly
reduced the initial burst release. In-vivo antidiabetic tests of chitosan (2%)-PEG (1.5%) scaffold formulation demonstrated
its ability to reduce blood sugar level for a prolonged duration (7 days). From this study, we concluded that, versatile
carrier system i.e. porous scaffold formulation is effective for the delivery of GLZ for diabetes mellitus and maintain
the concentration levels over a prolonged period of time, when compared against the free drug.
Keywords: Controlled delivery, gliclazide, 3-D porous matrix, scaffold, tissue engineering, sulfonylurea receptors, insulin, Chitosan, desiccators, supernatant, Entrapment efficiency, Gliclazide, pharmacodynamic study, freeze-drying, antidiabetic
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