Abstract
The mechanisms that regulate programmed cell death, such as apoptosis, and the cellular “selfeating” phenomenon of autophagy, share many regulatory systems and common pathways. These mechanisms have been extensively investigated over the last few years. Some intracellular structures may determine and control the autophagic fate of the cell such as the endoplasmic reticulum, mitochondria, and lysosomes. The coordination and interrelation of these organelles are crucial in maintaining calcium levels and general cellular homeostasis, as well as in regulating cell life and death under physiological and pathological conditions, including cancer, neurodegeneration, and aging. In this review, we discuss the crosstalk between the aforementioned organelles and their influence in apoptotic and autophagic processes.
Keywords: Apoptosis, autophagy, calcium signaling, calcium stores, endoplasmic reticulum, lysosomes, mitochondria, orchestration, homeostasis, programmed cell death, catabolic proteases, stress, macroautophagy, proton gradient, uniporter.
Current Molecular Medicine
Title:The Role of Calcium Stores in Apoptosis and Autophagy
Volume: 13 Issue: 2
Author(s): S. S. Smaili, G. J. S. Pereira, M. M. Costa, K. K. Rocha, L. Rodrigues, L. G. do Carmo, H. Hirata and Y.-T. Hsu
Affiliation:
Keywords: Apoptosis, autophagy, calcium signaling, calcium stores, endoplasmic reticulum, lysosomes, mitochondria, orchestration, homeostasis, programmed cell death, catabolic proteases, stress, macroautophagy, proton gradient, uniporter.
Abstract: The mechanisms that regulate programmed cell death, such as apoptosis, and the cellular “selfeating” phenomenon of autophagy, share many regulatory systems and common pathways. These mechanisms have been extensively investigated over the last few years. Some intracellular structures may determine and control the autophagic fate of the cell such as the endoplasmic reticulum, mitochondria, and lysosomes. The coordination and interrelation of these organelles are crucial in maintaining calcium levels and general cellular homeostasis, as well as in regulating cell life and death under physiological and pathological conditions, including cancer, neurodegeneration, and aging. In this review, we discuss the crosstalk between the aforementioned organelles and their influence in apoptotic and autophagic processes.
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Cite this article as:
Smaili S. S., S. Pereira J. G., Costa M. M., Rocha K. K., Rodrigues L., do Carmo G. L., Hirata H. and Hsu Y.-T., The Role of Calcium Stores in Apoptosis and Autophagy, Current Molecular Medicine 2013; 13 (2) . https://dx.doi.org/10.2174/1566524011313020003
DOI https://dx.doi.org/10.2174/1566524011313020003 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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