Neuroprotection & Mechanism of Ethanol in Stroke and Traumatic Brain Injury Therapy: New Prospects for an Ancient Drug

Author(s): Karam Asmaro, Paul Fu, Yuchuan Ding.

Journal Name: Current Drug Targets

Volume 14 , Issue 1 , 2013

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Abstract:

Effective efforts to screen for agents that protect against the devastating effects of stroke have not produced viable results thus far. As a result this article reviews the possible role of ethanol as a neuroprotective agent in stroke and traumatic brain injury (TBI). Previous studies have associated ethanol consumption with a decreased risk of ischemic stroke, suggesting a neuroprotective mechanism. The translation of this clinical knowledge into basic science research with the goal of new therapy for acute stroke patients remains in its initial stages. In a recent study involving rats, we have shown that ethanol administration, in the correct dose after stroke onset, protects against ischemia-induced brain injury. The purpose of this paper is to discuss ethanol’s neuroprotective properties in stroke when consumed as a preconditioning agent, in TBI with a positive blood alcohol content, and finally in stroke treatment, with the goal of using post-ischemia ethanol (PIE) therapy to ameliorate brain damage in the future.

Keywords: Ethanol, alcohol, stroke therapy, ischemia/reperfusion injury, traumatic brain injury therapy, neuroprotection

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Article Details

VOLUME: 14
ISSUE: 1
Year: 2013
Page: [74 - 80]
Pages: 7
DOI: 10.2174/1389450111314010008
Price: $58

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