Strategies to Improve the Clinical Performance of Chimeric Antigen Receptor-Modified T Cells for Cancer
Clinical trials of chimeric antigen receptor (CAR)-modified T cells have shown promise in hematologic malignancies.
However, in solid tumors, the clinical responses have been less impressive. It is important to determine how to
further improve the clinical effects of CAR-modified T cells. In this review, we focus on recent clinical trials and analyze
the factors that determine clinical responses, including the following: 1) the composition of the CAR; 2) the preparation of
CAR-modified T Cells; 3) the clinical treatment schedule; 4) the patient characteristics. We also propose future Strategies
that must be investigated before the technology can be used in a wider range of clinical applications.
Keywords: Adoptive cell therapy, chimeric antigen receptor, T cell, cancer immunotherapy, cancer gene therapy, clinical trial, T cell receptor, single chain fragment variable
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