Hemodynamic disturbance in cerebral blood flow (CBF) is common in both Alzheimer’s disease (AD) and
vascular dementia (VaD).The aim of this study is to investigate the different patterns of regional cerebral blood flow
(rCBF) change and cerebrovascular reactivity (CVR) in these two types of dementia. Mean flow velocity (MFV) of
middle cerebral artery and rCBF were measured by Transcranial Doppler ultrasound (TCD) and arterial spin-labeling
(ASL) magnetic resonance, separately. CVR was evaluated by MFV or rCBF change in response to 5% CO2 inhalation.
The ASL results showed that, rCBF was significantly lower in both the bilateral frontal and temporal lobes in AD group
and lower in left frontal and temporal white matter in patients with VaD. CVR calculated by rCBF was impaired more
severely in bilateral frontal cortices in AD. Conversely, TCD tests failed to demonstrate significant difference in MFV and
CVR between the two groups. It is concluded that the different patterns detected by ASL in resting rCBF change and
cerebrovascular reactivity in response to carbogen inhalation may serve as a potential marker to distinguish AD and VaD.
Keywords: Alzheimer’s disease, Arterial spin-labeling magnetic resonance, Cerebrovascular reactivity, Regional cerebral
blood flow, Vascular dementia
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