Migration, proliferation and apoptosis of vascular smooth muscle cells (VSMCs) have recently been identified
as important processes in a variety of human vascular diseases, including atherosclerosis, arterial injury, and restenosis
after angioplasty. These processes are regulated by interactions between the local cell-cell and cytokine environment.
Cytokine induced apoptosis inhibitor (CIAPIN1) is a novel antiapoptotic molecule and plays a vitally important role in
malignant phenotypes of cancers. However, the effect of CIAPIN1 on VSMCs has not been reported. In the present study,
we constructed the adenovirus encoding CIAPIN1 siRNA and transduced it into VSMCs. The results demonstrated that
CIAPIN1 siRNA inhibited proliferation, migration and promotes apoptosis of VSMCs by regulating Bcl-2 and Bax. Our
results suggest that CIAPIN1 siRNA might play the key role in VSMC biological function and provide the new
therapeutic strategy for vascular diseases.
Keywords: CIAPIN1, siRNA, VSMCs, Apoptosis, Bcl-2, Bax
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