Following "click chemistry" guidelines, a 1,2,3-triazole scaffold was introduced in place of a benzene ring to
mimic the non-classical cannabinoid pharmacophore model in a novel class of compounds aimed at CB1 receptor
agonism. The design, synthesis and results of receptor affinity tests for the new group of ligands are described. The
obtained series exhibited a similar sidechainlength-activity relationship as in the initial pharmacophore model, with
moderate CB1- selectivity.
Keywords: Cannabinoid, CB1 receptor, Triazole, Click chemistry, Non-classical cannabinoids, pharmacophore model, cycloaddition, lipophilic side chain, column chromatography, CP55940
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