Abstract
A series of Andrographolide derivatives were described and evaluated for their in vitro anti-HIV activity. Compound 11 and 21 showed significant anti-HIV-1 activity in C8166 cells. Since compound 11 had no cytotoxicity, it was expected to be new lead for further development of anti-AIDS agents.
Keywords: Andrographolide, Derivatives, Anti-HIV, C8166 cells, Natural products, Synthesis, Acquired immune deficiency syndrome, human immunodeficiency virus, RDCSY- I capillary apparatus, lymphocyte counts
Letters in Drug Design & Discovery
Title:Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives
Volume: 10 Issue: 2
Author(s): Guolong Gu, Haiyan Lin, Yajuan Liu, Liumeng Yang, Yongtang Zheng, Bin Wang, Chunlei Tang, Hai Qian and Wenlong Huang
Affiliation:
Keywords: Andrographolide, Derivatives, Anti-HIV, C8166 cells, Natural products, Synthesis, Acquired immune deficiency syndrome, human immunodeficiency virus, RDCSY- I capillary apparatus, lymphocyte counts
Abstract: A series of Andrographolide derivatives were described and evaluated for their in vitro anti-HIV activity. Compound 11 and 21 showed significant anti-HIV-1 activity in C8166 cells. Since compound 11 had no cytotoxicity, it was expected to be new lead for further development of anti-AIDS agents.
Export Options
About this article
Cite this article as:
Gu Guolong, Lin Haiyan, Liu Yajuan, Yang Liumeng, Zheng Yongtang, Wang Bin, Tang Chunlei, Qian Hai and Huang Wenlong, Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives, Letters in Drug Design & Discovery 2013; 10 (2) . https://dx.doi.org/10.2174/157018013804725107
DOI https://dx.doi.org/10.2174/157018013804725107 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Role of Autophagy in the Gut Pathogens Clearance and Evasion
Current Protein & Peptide Science Herpes Simplex Virus-Induced Ocular Diseases: Detrimental Interaction Between Virus and Host
Current Immunology Reviews (Discontinued) Computational Approaches for Predicting Causal Missense Mutations in Cancer Genome Projects
Current Bioinformatics Targeting Aurora Kinases in Cancer Treatment
Current Drug Targets Mesenchymal Stem Cells Promote Caspase Expression in Molt-4 Leukemia Cells <i>Via</i> GSK-3α/Β and ERK1/2 Signaling Pathways as a Therapeutic Strategy
Current Gene Therapy Novel and Emerging Drugs for Systemic Lupus Erythematosus: Mechanism of Action and Therapeutic Activity
Current Medicinal Chemistry Differential Network Analysis in Human Cancer Research
Current Pharmaceutical Design Oncogenic MicroRNAs in the Genesis of Leukemia and Lymphoma
Current Pharmaceutical Design Treatment of Lymphoid and Myeloid Malignancies by Immunomodulatory Drugs
Cardiovascular & Hematological Disorders-Drug Targets Indole-3-ethylsulfamoylphenylacrylamides with Potent Anti-proliferative and Anti-angiogenic Activities
Anti-Cancer Agents in Medicinal Chemistry Onconase and Amphinase, the Antitumor Ribonucleases from Rana pipiens Oocytes
Current Pharmaceutical Biotechnology Insulin and the Brain
Current Diabetes Reviews Edible Transgenic Plant Vaccines for Different Diseases
Current Pharmaceutical Biotechnology Transbronchial Needle Aspiration (TBNA): Past Present and Future
Current Respiratory Medicine Reviews Cytotoxic Potential of Phenothiazines
Current Drug Targets Helicobacter Pylori Infection, Immune Response and Vaccination
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Design Strategies, Structures and Molecular Interactions of Small Molecule Src Inhibitors
Anti-Cancer Agents in Medicinal Chemistry Cutting Edge: Chemoprevention of Colorectal Neoplasia in Inflammatory Bowel Disease
Inflammation & Allergy - Drug Targets (Discontinued) A Systems Biology Road Map for the Discovery of Drugs Targeting Cancer Cell Metabolism
Current Pharmaceutical Design Structural and Functional Organization of miRNAs
Current Pharmacogenomics