Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives
A series of Andrographolide derivatives were described and evaluated for their in vitro anti-HIV activity.
Compound 11 and 21 showed significant anti-HIV-1 activity in C8166 cells. Since compound 11 had no cytotoxicity, it
was expected to be new lead for further development of anti-AIDS agents.
Keywords: Andrographolide, Derivatives, Anti-HIV, C8166 cells, Natural products, Synthesis, Acquired immune deficiency syndrome, human immunodeficiency virus, RDCSY- I capillary apparatus, lymphocyte counts
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