Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Antibacterial Activity of Oxime Ester Derivatives from Dehydroabietic Acid

Author(s): Cui Yan-Jie, Rao Xiao-Ping, Shang Shi-Bin, Song Jie, Gao Yan-Qing.


A series of oxime ester derivatives containing dehydroabietyl group were synthesized from dehydroabietic acid. Their structures were characterized by IR, 1HNMR, MS, and elemental analysis. The preliminary antibacterial activity results indicate that these compounds display extensive anti-bacterial activity against Escherichia coli, Staphyloccocus aureu, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia aerogenes and Staphyloccocus epidermidis. Compounds (5a, 5b, 5c, 5d, 5e, 5f) exhibit excellent anti-bacterial activity against Escherichia coli with the diameter of inhibition zone is 10.91mm, 11.03mm, 12.92mm, 13.48mm , 11.59mm and 11.58mm respectively,compared with the diameter of inhibition zone of 9.66mm of the commercial compound bromogeramine. Furthermore, Compounds(5d) exhibited the same level of antibacterial activity against Staphyloccocus epidermidis when compared with bromogeramine and Ampicillin Na.

Keywords: Dehydroabietic acid, Oxime ester, Antibacterial activity, dehydroabietyl group, Oxime ester, pharmaceuticals, fungicidal, disproportionated, surfactants, rosin

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Article Details

Year: 2013
Page: [102 - 110]
Pages: 9
DOI: 10.2174/157018013804725071
Price: $58