Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Antibacterial Activity and Structure-activity Relationship Studies of 4- substituted-5-(diphenylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones

Author(s): Edyta Kusmierz, Agata Siwek, Urszula Kosikowska, Anna Malm, Joanna Stefanska, Katarzyna Dzitko, Monika Wujec.


Seventeen 4-substituted-5-(diphenylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones were synthesized and the structures of the compounds were determined by 1H NMR and IR spectra. In vitro antibacterial potency of all title compounds was evaluated. Additionally, the initial in vitro toxicity screening was performed for one compound using the MTT assay technique. A structure-activity relationship (SAR) studies have been carried out to determine the relevance of the different parameters that define the potency of title s-triazoles.

Keywords: Antimicrobial activity, s-triazole, Structure-activity relationship (SAR) studies, Toxicity, Sigma Aldrich, ampicillin, Gram-positive strains, Klebsiella pneumoniae, humidified environment, Staphylococcus epidermidis

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Article Details

Year: 2013
Page: [95 - 101]
Pages: 7
DOI: 10.2174/157018013804725198
Price: $58