Current Rheumatology Reviews

Dr. Serena Guiducci  
Department of Biomedicine, Division of Rheumatology
University of Florence
Florence
Italy

Back

Heart Valve Lesions In The Antiphospholipid Syndrome

Author(s): Ricard Cervera, Gerard Espinosa.

Abstract:

The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphospholipid antibodies (aPL), hypercoagulability leading to vascular thrombosis, and pregnancy morbidity. Since its recognition, a great number of cardiac manifestations have been reported in association with these antibodies, but heart valve abnormalities are the most common cardiac manifestations of the syndrome. They include valve thickness >3 mm, localized thickening involving the leaflet’s proximal or middle portion, and/or irregular nodules on the atrial face of the edge of the mitral valve, and/or the vascular face of the aortic valve. A consensus committee recommended anticoagulation in symptomatic valvular disease. Asymptomatic patients should be prophylactically treated with aspirin.

Keywords: Antiphospholipid antibodies, anticardiolipin antibodies, lupus anticoagulant, systemic lupus erythematosus.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 8
ISSUE: 3
Year: 2012
Page: [161 - 165]
Pages: 5
DOI: 10.2174/157339710803140210193810
Price: $58