Affective Disorder and Hyperandrogenism
Celen Zerouni, Elaine Kummerow, Mariflor Martinez, Ana Diaz, Uribe Ezequiel and Richard Wix-Ramos
Affiliation: Apartado Postal 3798, El trigal, Valencia, Venezuela.
A 40-year-old female patient with bipolar disorder and premenstrual dysphoric disorder did not present any
physical evidence of virilization, treated with quetiapine and lithium carbonate. Laboratory testing showed evidence of
hyperandrogenism (Testosterone levels 88.5ng/dL). After control, testosterone levels were normal (free testosterone 0.20
pg/ml, total testosterone 27.90ng/dl), as free thyroxine levels decreased (T4 0.83ng/dl) and increased progesterone levels
(progesterone 3.80ng/ml). We consider an association between increased androgenic hormone levels in women,
quetiapine and lithium carbonate treatment as well as the presence of an affective disorder and premenstrual dysphoric
disorder. Some relevant patents are also outlined in this review.
Keywords: Affective disorder, hormonal alteration, hyperandrogenism, premenstrual dysphoric disorder, quetiapine and
lithium carbonate treatment, Antiepileptic drugs, cognitive-affective disorders, hyperplasia, prostate cancer
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