Diabetic Nephropathy: Causes and Managements
Yamini B. Tripathi and Durgavati Yadav
Affiliation: Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi- 221005, UP, India.
Uncontrolled diabetic patients often develop diabetic nephropathy (DN). Since, it involves different molecular
pathways, such as polyol pathway, protein kinase - C (PKC) activation, inflammatory and oxidative stress etc., and so
multi-targeted drugs would be required for its management. Although, combination therapies with various conventional
medicines are already in use, but herbal preparations are being preferred as adjuvant therapy, because of their multi targeted
drug action due to the presence of natural cocktail of various secondary metabolites. This review describes pathogenesis
of DN, possible approaches for its management and information about recent patents and bio-products, which are
in pipe line of drug development.
Keywords: Chronic kidney disease, diabetic nephropathy, herbals, patented drugs, glomerular surface area, leucocytic infiltration, vascular remodeling, Hyperglycemic management, Hypertension management, Dietary Protein management
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