Cancer Therapy Based on a Mechanism of Action for Controlling the Immune System and the Resulting Patent Portfolio
Visala C. Goswitz and Z. Peter Sawicki
Affiliation: Westman, Champlin and Kelly, P.A. 900 Second Avenue South, Suite 1400; Minneapolis, MN 55402 USA.
Keywords: Allogeneic cells, cancer therapy, cytokines, HVG, HVT, immune cells, Mirror Effect™, IMMUNOTHERAPY, TH1/TH2 RESPONSE, IMMUNE CELLS
Despite decades of research, current cancer therapies extend survival but often do not actually cure the disease.
Immune cell based therapy is described here that can eliminate tumor cells without the toxicity associated with chemotherapy
or allogeneic bone marrow transplant (BMT). Allogeneic BMT has beneficial graft vs. tumor (GVT) effects but
accompanied by the undesirable graft vs. host disease (GVHD). The mechanism described here relates to generating the
Mirror Effect™ that elicits a host vs. tumor (HVT) effect along with a non-toxic host vs. graft (HVG) response. The HVT
effect generated by inducing the Mirror Effect™ in a host is effective in cancer therapy, as well as other diseases. The
patent strategy, employed for successful patent prosecution related to the elucidation of the Mirror Effect™, is also discussed.
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