Trends in Patents of Enzymatic Biomarkers for Early Detection of Bacteria
Savio Morato de Lacerda Gontijo, Luis F. Morgan, Celia R.M. Lanza, Tamara L. Rodriguez, Claudio R. Martinez, Ruben D. Sinisterra and Maria E. Cortes
Affiliation: Restorative Dentistry, Dentistry Faculty, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, CEP 31270-901 Belo Horizonte, MG, Brazil.
Delayed or improper diagnosis of bacterial infection can result in sepsis, serious, and often deadly or inflammatory
response. Thus, there is a need for a simple assay that can detect low levels of bacteria, which are faster and sensitive
in order to provide data for establish treatment decisions in a clinically relevant time frame. Advances in materials research
and molecular biology play an important role in understand and development the best way for bacterial diagnosis
kits and methods to reach specific targets from the cellular metabolism such as particular enzymes. Recent changes in the
diagnostic methods are using simple techniques especially focus to distinguish enzymatic reactions, dependent on substrate
and biochemical allowing the bacteria presence detection by very fast reactions. This review highlights the state-ofart
in patents of enzymatic biomarkers for early detection of bacteria based-on nanostructures chromogenic or fluorogenic.
Keywords: Bacteria, chromogenic, diagnosis, early detection, enzymatic biomarkers, fluorogenic, Nanostructures, nanodevices, Enzyme-substrates, Coumarin derivatives
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