Alteration of the Beta-Adrenergic Signaling Pathway in Human Heart Failure

Author(s): Nazha Hamdani , Wolfgang A. Linke .

Journal Name: Current Pharmaceutical Biotechnology

Volume 13 , Issue 13 , 2012

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Abstract:

Heart failure is characterized by elevated circulating catecholamine levels and extensive abnormalities in β-adrenergic receptor signaling. Under physiological conditions, sympathetic modulation via catecholamines induces positive inotropic, chronotropic and lusitropic responses. Well established in heart failure patients is a pronounced activation of the sympathetic system, accompanied by downregulation and desensitization of β-adrenergic receptors, leading to a markedly diminished β-adrenergic contractile response. In this review, we will discuss the normal β-adrenergic receptor signaling pathway in the heart and focus on the pathphysiological alterations of β-adrenergic receptor signaling and contractile proteins in heart failure.

Keywords: Heart failure, β adrenergic receptors, myofilament proteins, cardiomyocytes

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Article Details

VOLUME: 13
ISSUE: 13
Year: 2012
Page: [2522 - 2531]
Pages: 10
DOI: 10.2174/1389201011208062522
Price: $58

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