Abstract
Statins exert several beneficial effects on patients with peripheral arterial disease, whether managed conservatively or undergoing open surgical/endovascular procedures. Statins improve perioperative and long-term mortality and morbidity rates in these patients. There is also evidence that statins improve infrainguinal bypass graft patency rates and are associated with reduced graft restenosis and amputation rates in these procedures. This review considers the beneficial effects of statins on patients undergoing infrainguinal bypass graft procedures and discusses the implicated pathomechanisms.
Keywords: Statins, peripheral arterial disease, infrainguinal bypass graft operation perioperative mortality and morbidity, peripheral endovascular procedures, 3-hydroxy-3-methylglutaryl coenzyme A, abdominal aortic aneurysms, extremity functions
Current Vascular Pharmacology
Title:Statins and Infrainguinal Vascular Bypass Procedures
Volume: 11 Issue: 1
Author(s): Kosmas I. Paraskevas, Athanasios D. Giannoukas and Dimitri P. Mikhailidis
Affiliation:
Keywords: Statins, peripheral arterial disease, infrainguinal bypass graft operation perioperative mortality and morbidity, peripheral endovascular procedures, 3-hydroxy-3-methylglutaryl coenzyme A, abdominal aortic aneurysms, extremity functions
Abstract: Statins exert several beneficial effects on patients with peripheral arterial disease, whether managed conservatively or undergoing open surgical/endovascular procedures. Statins improve perioperative and long-term mortality and morbidity rates in these patients. There is also evidence that statins improve infrainguinal bypass graft patency rates and are associated with reduced graft restenosis and amputation rates in these procedures. This review considers the beneficial effects of statins on patients undergoing infrainguinal bypass graft procedures and discusses the implicated pathomechanisms.
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Cite this article as:
I. Paraskevas Kosmas, D. Giannoukas Athanasios and P. Mikhailidis Dimitri, Statins and Infrainguinal Vascular Bypass Procedures, Current Vascular Pharmacology 2013; 11 (1) . https://dx.doi.org/10.2174/1570161111309010051
DOI https://dx.doi.org/10.2174/1570161111309010051 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
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