Antiplatelet therapy plays an important role in the management of atherosclerotic disease and numerous studies
have shown their efficacy in the reduction of cardiovascular mortality and morbidity. Antiplatelets are given in patients
subjected to lower limb bypass aiming not only to reduce cardiovascular mortality and morbidity but also improve graft
patency. Various antiplatelet agents have been used for this purpose. The aim of this review article is to critically evaluate
the existing evidence on the impact of antiplatelet therapy for maintaining infrainguinal graft patency and highlight the
mechanisms involved along these lines.
Keywords: Antiplatelet agents, peripheral arterial disease, infrainguinal bypass, graft patency, aspirin, clopidogrel, ticlopidine, ticlopidine, Lower limb atherosclerosis, femoropopliteal
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