Abstract
We screened for selective inhibitors of mammalian DNA polymerase (Pol) species from natural products. We then identified compounds that are potential anticancer agents based on Pol inhibition. In this review, the focus is on symbiotic microorganisms that grow on wild marine plants and which could be used as a new screening source for anticancer compounds. The fungal strains were isolated from wild marine plants such as seaweeds and sea mosses collected in Japan. Nine novel compounds were isolated from the cultured broth extracts of isolated fungal strains. These compounds showed bioactivities such as selective inhibition of mammalian Pol activity among 10 mammalian Pol species and suppression of proliferation of human cancer cells while having no effect on the growth of normal human cells. The probability of discovering novel compounds from such sources is high. Therefore, microorganisms derived from wild marine plants appear to be a good screening source for bioactive compounds compared with other naturally occurring materials.
Keywords: Marine microorganism, Seaweeds, Sea mosses, DNA polymerase (E.C.2.7.7.7), Enzyme inhibitor, Cytotoxicity, Anticancer drug
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
27