The ultraviolet-B (UVB)–vitamin D–cancer hypothesis was proposed in 1980 yet has not been fully accepted. Ecological
studies based on geographical variations of cancer rates with respect to solar UVB doses have supported the hypothesis for about 20
cancers. This paper reviews the evidence from studies of personal or group UVB irradiance. Studies have associated personal UVB
irradiance with reduced risk for breast, colon, endometrial, prostate, and renal cancer, as well as non-Hodgkin’s lymphoma (NHL).
However, some studies have also found increased risk of NHL from UV irradiance, probably due to immunosuppression by UVA near
370 nm. Several related approaches have also been used to study the hypothesis. Studies in Norway and the UK found that diagnosis in
summer or fall is associated with increased survival rates for breast, colon, lung, and prostate cancer, as well as Hodgkin’s lymphoma.
Diagnosis of nonmelanoma skin cancer is associated with reduced risk of several cancers in sunny countries, but not often in highlatitude
countries. Living at higher surface elevation is associated with reduced risk of some cancers. In a recent analyzed study of cancer
rates for 54 occupations in Nordic countries, a UVB index based on standardized incidence ratios of lip cancer less those for lung cancer
was inversely correlated with 15 types of cancer for males, but only four types for females. This ecological study provides additional
evidence that UVB doses at high latitudes are adequate to reduce the risk of cancer, but requires considerable time outside to produce
sufficient vitamin D. Because only vitamin D production has been proposed to explain the UVB–cancer link, studies reviewed in this
paper should be considered strong evidence for the hypothesis.
Keywords: Breast cancer, Colon cancer, Ecological study, Endometrial cancer, Hill’s criteria for causality, Immunosuppression, Melanoma, Non-Hodgkin’s lymphoma, Nonmelanoma skin cancer, Nordic countries, Observational study, Randomized controlled trial, Renal cancer, Ultraviolet-A, Ultraviolet-B, Vitamin D
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