Now-a-days, cancer is becoming one of the major problems of public health in the world. Pharmacology
treatment is a way to increase quality and long life. Predominantly, in last decade sulfonamide derivatives have been
described as potential carbonic anhydrase inhibitors. In the present work, we describe recent advances during the last
decade in medicinal chemistry of sulfonamides derivatives with some examples of rational design as anti-tumoral, antibacterial
and anti-inflammatory agents. We show strategy design, structure-activity relationship, biological activity and
advances of new sulfonamide compounds that have more health significance than some clinically used sulfonamides.
Keywords: Anti-bacterial, Anti-inflammatory, Anti-tumoral, Biological activity, Sulfonamide, Structure-activity relationship,
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