The main challenge encountered while treating using Paclitaxel (PTX) is its poor solubility in aqueous solutions. The cremophor
used in the formulation can cause various side effects such as hypersensitivity, myelosuppression and neurotoxicity and also leads to
non-specific distribution in tumor and normal tissues. Since the structure of Paclitaxel does not possess a functional group, it is not easy
to manipulate to enhance the solubility. Such limitations can be overcome by delivering Paclitaxel with the aid of drug delivery systems
such as polymeric micelles, nanoparticles, hydrogels and liposomes. The review discusses various approaches of Paclitaxel delivery via
polymeric nanoparticles. It focuses on the passive and active targeting of Paclitaxel.
Keywords: Active, cancer, drug, nanoparticles, paclitaxel, passive, pH, polymer
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