Cardiac Regeneration: Stem Cells and Beyond

Author(s): A. T. Moerkamp, Marie-Jose Goumans.

Journal Name: Current Medicinal Chemistry

Volume 19 , Issue 35 , 2012

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Abstract:

After myocardial infarction, the lost healthy myocardium is replaced by non-contractile scar tissue which may lead to the development of heart failure and death. There is no curative therapy for the irreversible myocardial cell loss. This review will give an overview of the current options to restore the contractile force of the heart: the different stem cell sources as therapeutic agents in cardiac repair as well as more novel approaches like the activation of endogenous cell populations, the use of paracrine factors and engineered heart tissue.

Keywords: Cardiac regeneration, endogenous cell populations, paracrine factors, stem cell therapy, tissue engineering

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Article Details

VOLUME: 19
ISSUE: 35
Year: 2012
Page: [5993 - 6002]
Pages: 10
DOI: 10.2174/0929867311209065993
Price: $58

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