Frontiers in Medicinal Chemistry

Volume: 6

Indexed in: Scopus, Book Citation Index, Science Edition (BKCI-S), Web of Science, BIOSIS Previews, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals

“Frontiers in Medicinal Chemistry” is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. “Frontiers in ...
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Antimicrobial Peptides in Oral Cancer: Review Article

Pp. 131-153 (23)

Christina Roebke, Jürgen Harder and Jens E. Meyer

Abstract

There is increasing evidence that Antimicrobial Peptides (AMPs) are differentially regulated in cancers such as Oral Squamous Cell Carcinomas (OSCC). Data showing that AMPs influence the growth of tumor cells, exhibit direct cytotoxic activity towards cancer cells, function as a tumor suppressor gene or activate the adaptive immunity suggest that a dysregulation of AMPs may be associated with the development of cancer. There is no question that, with increasing resistance against conventional chemotherapy, novel anticancer agents are needed. It is interesting to speculate that natural AMP or synthetic derivatives can be used to develop novel strategies to fight cancer diseases and may represent a novel family of anticancer agents. However, future research is needed to employ the role of AMPs in cancer and to investigate their role as potential anticancer drugs.

Keywords:

Antimicrobial peptide, defensin, cathelicidin, histatin, adrenomedullin, oral cancer, immunotherapy, anticancer effect.

Affiliation:

Department of Otorhinolaryngology, Head, Neck and Plastic Surgery, Lohmuehlenstr. 5, 20099 Hamburg, Germany.