TAVI: Trans-Catheter Aortic Valve Implantation
Pp. 256-288 (33)
Wilhelm Peter Mistiaen
For patients deemed unfit to undergo AVR, BAV has been tried as a less
traumatic alternative. Recurrence of stenosis within months has been observed,
however. BAV has been abandoned, and alternatives have been explored.
Implantation of a valve through a catheter has proven experimentally feasible and has
been performed for the first time in a patient in 2003. The more cumbersome transseptal
technique has been replaced by the trans-arterial technique. This procedure has
not always been applicable in patients with atheromatosis of the femoral and iliac
arteries or of the aorta. As alternative, a trans-apical approach has been developed.
TAVI might also become attractive as “valve-in-valve” procedure, for patients with a
The current procedure needs an elaborate imaging system, with a pre-procedural study
of the anatomy of the aortic root. Interference with anatomical structures such as the
coronary arteries and the conduction system needs to be avoided. Attachment and
anchoring systems needs to be adequate, to avoid secondary displacement.
The selection of patients is problematic: the EuroSCORE tends to overestimate
operative mortality of conventional AVR, especially in high risk patients. Such patients
might be denied this operation unjustly. A RCT, comparing TAVI with medical
treatment and with conventional AVR might seem desirable.
The early clinical and hemodynamic results in terms of TVG and AVA seem acceptable
but PPVL could be a problem. A recently published RCT, which compared medical
treatment or BAV with TAVI, showed superior clinical and hemodynamic results for
the latter. PPVL has been considered as acceptable and has not worsened after one year.
Vascular complications, bleeding an stroke have been troubling. Technical
improvements with smaller delivery systems might offer relief. A second RCT has
shown the non inferiority of TAVI, compared to conventional AVR, at least for the first
postoperative year. TAVI offers the advantage of being less traumatic, compared to
These results make clear that TAVI is here to stay.
Balloon aortic valvotomy, bleeding, conventional aortic valve
replacement, EuroSCORE, exclusion criteria, imaging, life expectancy,
paravalvular leak, percutaneous devices, quality of life, randomized controlled
trial, stroke, transapical, transarterial, vascular complications.
Artesis University College Antwerp Department of Healthcare Sciences University of Antwerp Belgium