Degenerative Aortic Valve Disease, its Mechanism on Progression, its Effect on the Left Ventricle and the Postoperative Results

Indexed in: Scopus

"Degenerative aortic valve disease is the most prominent cardiac valve disease in Western societies. This volume describes some of the more important issues and problems for this condition: its ...
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Pathology of CAVS

Pp. 21-62 (42)

Wilhelm Peter Mistiaen


The pathological changes in CAVS are much more than a simple age related “wear and tear”. There is some resemblance of CAVS with atherosclerosis, but important differences have also been authenticated. Both conditions share a number of risk factors, however

The mechanisms leading to the microscopically observable changes in CAVS include many molecules and pathways. There is a considerable “cross talk” between these mechanisms which makes their description difficult.

The unravelling of these pathways requires a description in layers.

The outer layer consists of the risk factors of which the most common are lipid disorders and hypertension.

The middle layer consists of the molecules and mediators involved. Some of these molecules are inflammatory, others are the result of mechanical or oxidative stress, still others play a role in the remodelling of the ECM.

The inner layer consists of the mechanisms, which are inflammation, calcification or ossification, angiogenesis, remodelling of the ECM and programmed cell death.

The unravelling of these processes in CAVS is an ongoing process and is still not completely understood. This understanding might have some consequences in terms of prevention or slowing down of the process.


Angiotensin, apoptosis, atheromatosis, autophagy, calcification, Heyde’s syndrome, inflammation, lipid infiltration, mechanical stress, neoangiogenesis, osteoblastic differentiation, oxidative stress, vitamin K antagonists.


Artesis University College Antwerp Department of Healthcare Sciences University of Antwerp Belgium