A new multidentate ligand (L) has been synthesized by the controlled condensation of L-glutamic acid with
formaldehyde and ethylenediamine. Cu(II) and Ru(III) metal ion complexes of the synthesized ligand have also been prepared.
The ligand and the metal complexes were purified by chromatography and characterized by spectroscopy and other
techniques. Molar conductance measurements suggested ionic nature of the complexes. The ligand and the complexes are
soluble in water with quite good stabilities; essential requirements for effective anticancer drugs. DNA binding constants
(Kbs) for copper and ruthenium complexes were 1.8 x 103 and 2.6x103 M-1 while their Ksv values were 7.9x103, and
7.310x3; revealing strong binding of these complexes with DNA. Hemolytic assays of the reported compounds indicated
their significantly less toxicity to RBCs than the standard anticancer drug letrazole. Anticancer profiles of all the compounds
were determined on HepG2, HT-29, MDA-MB-231 and HeLa human cancer cell lines. All the compounds have
quite good activities on HeLa cell lines but the best results were of CuL on HepG2, HT-29 and MDA-MB-231 cell lines.
Keywords: L-Glutamic acid Derivative, Copper and Ruthenium Complexes, Molar conductance measurements, DNA binding studies, Hemolytic assays, Solution Stability and Anticancer Cell Line Activities
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