Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species

Author(s): Peter Kovacic , Ratnasamy Somanathan .

Journal Name: Current Neuropharmacology

Volume 10 , Issue 4 , 2012

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Abstract:

Much attention has been devoted to neurodegenerative diseases involving redox processes. This review comprises an update involving redox processes reported in the considerable literature in recent years. The mechanism involves reactive oxygen species and oxidative stress, usually in the brain. There are many examples including Parkinson’s, Huntington’s, Alzheimer’s, prions, Down’s syndrome, ataxia, multiple sclerosis, Creutzfeldt-Jacob disease, amyotrophic lateral sclerosis, schizophrenia, and Tardive Dyskinesia. Evidence indicates a protective role for antioxidants, which may have clinical implications. A multifaceted approach to mode of action appears reasonable.

Keywords: Redox, neurodegenerative diseases, reactive oxygen species, oxidative stress

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2012
Page: [289 - 302]
Pages: 14
DOI: 10.2174/1570159X11209040289
Price: $58

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