Much attention has been devoted to neurodegenerative diseases involving redox processes. This review
comprises an update involving redox processes reported in the considerable literature in recent years. The mechanism
involves reactive oxygen species and oxidative stress, usually in the brain. There are many examples including
Parkinson’s, Huntington’s, Alzheimer’s, prions, Down’s syndrome, ataxia, multiple sclerosis, Creutzfeldt-Jacob disease,
amyotrophic lateral sclerosis, schizophrenia, and Tardive Dyskinesia. Evidence indicates a protective role for
antioxidants, which may have clinical implications. A multifaceted approach to mode of action appears reasonable.