Adenovirus-based Immunotherapy for Prostate Cancer

Author(s): Seema Dubey, Peter VanVeldhuizen, Dev Karan.

Journal Name:Current Cancer Therapy Reviews

Volume 8 , Issue 4 , 2012

Abstract:

Prostate cancer is a significant health problem for men in the United States. While useful treatment modalities are available, their therapeutic efficacies are limited and severe side effects remain a concern. Alternatively, immunotherapy represents one of the most valuable treatments by inducing immune response targeting tumor cells. Sipuleucel-T is the only FDA approved immunotherapeutic agent for the treatment of patients with metastatic castration-resistant prostate cancer. Overall survival benefit with sipuleucel-T is modest, and the research field of cancer immunotherapy is continuously expanding. Numerous methods designed to induce tumor-specific immunity are at various developmental stages in clinical and preclinical studies. Among such modalities, the use of adenovirus vector (Ad) as an immunotherapy agent to deliver tumor-associated antigens is an attractive and versatile vector system. In this review, we describe the potential use of Ad-vector for prostate cancer immunotherapy.

Keywords: Prostate cancer vaccine, adenovirus vaccine, immunotherapy

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Article Details

VOLUME: 8
ISSUE: 4
Year: 2012
Page: [264 - 270]
Pages: 7
DOI: 10.2174/1573394711208040264
Price: $58