Heart failure (HF) is a condition with high mortality worldwide characterized by persistent progression. Myocardial
hypertrophy is a dominant feature during the early stage of HF. The development of HF is a complex process related
to a series of physiologic and molecular factors. Although the treatment of HF has been changed during the past century,
the knowledge on its molecular mechanism is still very limited. The review herein tries to touch the molecular basis
underlying HF and discusses the relevance between HF and other diseases such as thrombosis. Furthermore, we believe
that the global alterations during progression of HF revealed by high content screening techniques may facilitate our understanding
on HF, and thereby the development of new therapeutics with less side effect.
Keywords: Extracellular matrix, heart failure, integrin, myocardial hypertrophy, signaling pathway, and thrombosis.
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