A New Method for a Quantitative Determination of Piroxicam in Pharmaceutical Formulations Using FT-IR Spectrometry
Andrei A. Bunaciu,
Hassan Y. Aboul-Enein.
A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, and direct measurement
of piroxicam (Pir) in pharmaceutical drugs. Pir is a well known and very effective antiinflammatory drug. Pir can
be determined by various methods and now we are adding a new one that uses a Fourier transform infrared spectrophotometric
technique. Conventional spectra were compared for best determination of active substance in pharmaceutical
formulations. The Beer-Lambert law and two chemometric approaches, partial least squares (PLS) and principal component
regression (PCR+) methods, were tried in data processing.
Keywords: FT-IR analysis, piroxicam, chemometric methods, drug analysis.
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