A New Method for a Quantitative Determination of Piroxicam in Pharmaceutical Formulations Using FT-IR Spectrometry

Author(s): Andrei A. Bunaciu, Serban Fleschin, Hassan Y. Aboul-Enein.

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Volume 11 , Issue 3 , 2012

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Abstract:

A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, and direct measurement of piroxicam (Pir) in pharmaceutical drugs. Pir is a well known and very effective antiinflammatory drug. Pir can be determined by various methods and now we are adding a new one that uses a Fourier transform infrared spectrophotometric technique. Conventional spectra were compared for best determination of active substance in pharmaceutical formulations. The Beer-Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods, were tried in data processing.

Keywords: FT-IR analysis, piroxicam, chemometric methods, drug analysis.

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Article Details

VOLUME: 11
ISSUE: 3
Year: 2012
Page: [262 - 266]
Pages: 5
DOI: 10.2174/1871523011202030262
Price: $58

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