Reduction of lung inflammation is one of the goals in the treatment of cystic fibrosis (CF). As a result, antiinflammatory
therapies are often used to decrease the excessive and persistent inflammatory response. Although effective,
the use of systemic corticosteroids has been limited due to unacceptable adverse effects. Inhaled corticosteroids (ICS) are
often used empirically to treat children and adults with CF despite the lack of evidence of their benefit. Concern about effects
on growth and adrenal suppression have been reduced, but not eliminated with the use of ICS. Herein, mechanisms
of action of corticosteroids, the effectiveness and safety of ICS usage in CF are reviewed.
Keywords: Inhaled corticosteroids, cystic fibrosis, adverse effects
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