Inhaled Corticosteroids In Treatment of Cystic Fibrosis

Author(s): Ela Erdem , Refika Ersu .

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Volume 11 , Issue 3 , 2012

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Reduction of lung inflammation is one of the goals in the treatment of cystic fibrosis (CF). As a result, antiinflammatory therapies are often used to decrease the excessive and persistent inflammatory response. Although effective, the use of systemic corticosteroids has been limited due to unacceptable adverse effects. Inhaled corticosteroids (ICS) are often used empirically to treat children and adults with CF despite the lack of evidence of their benefit. Concern about effects on growth and adrenal suppression have been reduced, but not eliminated with the use of ICS. Herein, mechanisms of action of corticosteroids, the effectiveness and safety of ICS usage in CF are reviewed.

Keywords: Inhaled corticosteroids, cystic fibrosis, adverse effects

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Article Details

Year: 2012
Page: [206 - 209]
Pages: 4
DOI: 10.2174/1871523011202030206
Price: $58

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