Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Antimicrobial Activity of some Amide Derivatives Bearing Thiazole, Benzhydryl and Piperidine Moieties

Author(s): Ahmet Ozdemir.


In the present study, N-(benzhydryl/thiazol-2-yl)-2-(piperidin-1-yl)acetamide derivatives were obtained by the reaction of 2-chloro-N-(benzhydryl/thiazole-2-yl)acetamides with piperidine derivatives. The chemical structures of the compounds were elucidated by IR, 1H-NMR, and mass spectral data and elemental analyses. These compounds were investigated for their antimicrobial effects. The microbiological results revealed that the compounds were more effective against C. albicans (ATCC-22019) than bacteria. Among all compounds (1-9), compound 3 bearing benzhydryl and 4- methylpiperidin-1-yl moieties was found to be the most effective compound against C. albicans. Compound 3 exhibited antibacterial activity against P. aeruginosa with a MIC value of 62.5 μg/mL, whereas streptomycin showed antibacterial activity against P. aeruginosa with a MIC value of 125 μg/mL. Furthermore, compound 3 exhibited the same level of antibacterial activity against S. aureus when compared with streptomycin. Other derivatives did not show significant activity against the tested bacteria.

Keywords: Amide, Thiazole, Benzhydryl, Piperidine, Antimicrobial activity, Cephalosporins, N-Alkylamides, Listeria monocytogenes, Pseudomonas aeruginosa, Mueller–Hinton

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Article Details

Year: 2013
Page: [44 - 48]
Pages: 5
DOI: 10.2174/1570180811309010044