m-Hydroxymexiletine (MHM), a minor metabolite of the class IB anti-arrhythmic drug mexiletine, is about two
fold more potent than the parent compound on human cardiac voltage-gated sodium channels (hNav1.5), and equipotent
to mexiletine on human skeletal-muscle voltage-gated sodium channels (hNav1.4). Herein, an alternative and simplified
synthesis of this promising compound has been accomplished. This route, as well as being more efficient, has the
advantage, over the first, to avoid the use of oxidizing agents, such as the meta-chloroperoxybenzoic acid.
Keywords: Anti-arrhythmics, Hydroxylation, hNav1.4, hNav1.5, Metabolite switch, m-Hydroxymexiletine, Sodium channel
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