Recent Patents on Catalysis (Discontinued)

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Synthesis of Dihydropyridines: Patented Catalysts and Biological Applications

Author(s): Laura M. Sanchez, Angel G. Sathicq, Horacio J. Thomas and Gustavo P. Romanelli

Affiliation: Centro de Investigacion y Desarrollo en Ciencias Aplicadas “Dr. J. J. Ronco” (CINDECA), Departamento de Quimica, Facultad de Ciencias Exactas, UNLP-CCT-CONICET. Calles 47 N° 257, B1900AJK La Plata, Argentina.

Keywords: Biological applications, dihydropyridines, Hantzsch reaction, patented catalysts.

Abstract:

The present review focuses on the patented synthetic methods and numerous pharmaceutical applications of 1,4-dihydropyridines. They were originally prepared by the Hantzsch multicomponent reaction, but nowadays there are several new methods. They have improved reaction yield and have reduced the risks of contaminating the environment. These improvements were achieved through the use of different catalytic systems, a variety of reaction solvents, and also some reactions were carried out without either catalyst or reaction solvent.

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Article Details

VOLUME: 1
ISSUE: 2
Page: [119 - 128]
Pages: 10
DOI: 10.2174/2211548X11201020119