Detection of Gram-Negative β-Lactamase Producing Pathogens in the Clinical Lab

Kenneth      S. Thomson

Abstract

Pathogens that produce extended spectrum β-lactamases (ESBLs), plasmid-mediated AmpC β-lactamases, and carbapenemases may appear falsely susceptible to β-lactam antibiotics in the laboratory. Infected patients may be treated with inappropriate antibiotics if laboratories do not perform accurate tests to detect these resistance mechanisms. Furthermore the resistant pathogens may spread undetected to amplify the therapeutic and infection control challenge. This review makes a case for why and how laboratories should perform tests to detect β-lactamase-mediated resistance in gram-negative pathogens.

Keywords: β-lactamase, ESBL, CTX-M, AmpC, carbapenemase, KPC, metallo-β-lactamase

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Current Pharmaceutical Design

Title:Detection of Gram-Negative β-Lactamase Producing Pathogens in the Clinical Lab

Volume: 19 Issue: 2

Author(s): Kenneth S. Thomson

Affiliation:

Keywords: β-lactamase, ESBL, CTX-M, AmpC, carbapenemase, KPC, metallo-β-lactamase

Abstract: Pathogens that produce extended spectrum β-lactamases (ESBLs), plasmid-mediated AmpC β-lactamases, and carbapenemases may appear falsely susceptible to β-lactam antibiotics in the laboratory. Infected patients may be treated with inappropriate antibiotics if laboratories do not perform accurate tests to detect these resistance mechanisms. Furthermore the resistant pathogens may spread undetected to amplify the therapeutic and infection control challenge. This review makes a case for why and how laboratories should perform tests to detect β-lactamase-mediated resistance in gram-negative pathogens.

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Cite this article as:

S. Thomson Kenneth, Detection of Gram-Negative β-Lactamase Producing Pathogens in the Clinical Lab, Current Pharmaceutical Design 2013; 19 (2) . https://dx.doi.org/10.2174/1381612811306020250

DOI https://dx.doi.org/10.2174/1381612811306020250	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286

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