Synthesis of Spiro-heterocycles via 1,3-Dipolar Cycloadditions of Nitrilimines to Exoheterocyclic Enones. Site-, Regio- and Stereo-Selectivities Overview

Author(s): Ahmad Sami Shawali , Abdou Osman Abdelhamid .

Journal Name: Current Organic Chemistry

Volume 16 , Issue 22 , 2012

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Abstract:

This review provides a survey on the reactions of nitrilimines, generated in situ by dehydrohalgenation of the corresponding hydrazonoyl halides, with heterocyclic enones. These reactions proved useful for synthesis of various spiroheterocycles possessing chiral centers and some biological activities.

Keywords: Heterocycles, Hydrazonoyl halides, Nitrilimines, Spiroheterocycles

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Article Details

VOLUME: 16
ISSUE: 22
Year: 2012
Page: [2673 - 2689]
Pages: 17
DOI: 10.2174/138527212804004553
Price: $58

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