Rheumatoid arthritis is a chronic auto-immune disease that is characterized by both localized and systemic
inflammation of internal organs and joints. Elevated plasma concentrations of pro-inflammatory cytokines, such as
interleukin-6 (IL-6), interleukin-1b (IL-1b), tumor necrosis factor- α (TNF-α), and acute phase proteins, are responsible
for both localized and systemic inflammation. Rheumatoid arthritis is a disease which is affecting 1–1.5% of the
population worldwide and females are more affected than male, with a ratio of 2:1. Rheumatoid arthritis symmetrically
affect both side of joints i.e., interphalangeal joints such as the proximal interphalangeal, metacarpophalangeal, and
metatarsophalangeal joints of the hands and feet as well as the wrist and ankle. There are number of drugs molecules
available for treatment of rheumatoid arthritis which have limited efficiency with serious side effects. After the
development of targeted drug delivery system, the panic of adverse effects and toxicity has been reduced for other nontarget
body organs. Furthermore, the efficiency of drugs towards target site has also increased. With this review our group
tried to discuss various novel strategies available for the treatment of autoimmune disease i.e., rheumatoid arthritis.
Keywords: Folate, Immunotherapy, Monoclonal antibodies, Angiogenesis, Dendritic cells, Tyrosine kinase.
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