Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) make significant contributions to gastric ulcer disease which remains widespread. Although several factors have been postulated as pathogenic elements of the gastric injury induced by NSAIDs, it is, however believed that prostaglandin deficiency plays a critical role in the pathogenesis of this injury. During prostaglandin deficiency, other defensive mechanisms might operate to attenuate NSAID-induced gastropathy. According to our results, NSAIDs, similar to stress, induce an increase in glucocorticoid production that in turn helps the gastric mucosa to resist the harmful actions of these drugs. In this article, we review our experimental data suggesting that glucocorticoids may play a role as natural defensive factors in maintaining the integrity of the gastric mucosa during NSAID therapy and might operate to attenuate NSAID-induced gastropathy.
Keywords: Nonsteroidal anti-inflammatory drugs, indomethacin, aspirin, gastric erosion, the hypothalamic-pituitary-adrenocortical axis, glucocorticoids, gastroprotection, ulcer, injury, gastric mucosa
Current Pharmaceutical Design
Title:Gastroprotective Role of Glucocorticoids During NSAID-induced Gastropathy
Volume: 19 Issue: 1
Author(s): Ludmila Filaretova
Affiliation:
Keywords: Nonsteroidal anti-inflammatory drugs, indomethacin, aspirin, gastric erosion, the hypothalamic-pituitary-adrenocortical axis, glucocorticoids, gastroprotection, ulcer, injury, gastric mucosa
Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) make significant contributions to gastric ulcer disease which remains widespread. Although several factors have been postulated as pathogenic elements of the gastric injury induced by NSAIDs, it is, however believed that prostaglandin deficiency plays a critical role in the pathogenesis of this injury. During prostaglandin deficiency, other defensive mechanisms might operate to attenuate NSAID-induced gastropathy. According to our results, NSAIDs, similar to stress, induce an increase in glucocorticoid production that in turn helps the gastric mucosa to resist the harmful actions of these drugs. In this article, we review our experimental data suggesting that glucocorticoids may play a role as natural defensive factors in maintaining the integrity of the gastric mucosa during NSAID therapy and might operate to attenuate NSAID-induced gastropathy.
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Cite this article as:
Filaretova Ludmila, Gastroprotective Role of Glucocorticoids During NSAID-induced Gastropathy, Current Pharmaceutical Design 2013; 19 (1) . https://dx.doi.org/10.2174/1381612811306010029
DOI https://dx.doi.org/10.2174/1381612811306010029 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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