Design, Synthesis and In Vitro Anti-Mycobacterial Activity of Chromene Fused Cytosine and Uracil Analogues
Nimesh R. Kamdar,
Dhaval D. Haveliwala,
Prashant T. Mistry,
Saurabh K. Patel.
A series of chromene fused cytosine and uracil were prepared by the condensation of thiourea or carbon disulphide
with 2-amino-7,7-dimethyl-5-oxo-4-(substituted phenyl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile. The newly
synthesized compounds were characterized by IR, 1H-NMR, Elemental analysis and some representative 13C-NMR and
Mass spectra. All the title compounds were evaluated for antitubercular and antimicrobial activities against various mycobacterial,
bacterial and fungal strains. Some of the compounds have shown promising antimicrobial and antitubercular
activity while others were inactive.
Keywords: Antimicrobial activity, antitubercular activity, chromene, fused cytosine, fused uracil.
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