Citrus Flavonoids and the Prevention of Atherosclerosis
Erin E. Mulvihill,
Murray W. Huff.
Epidemiological studies have demonstrated that diets rich in fruits and vegetables can prevent or delay the
onset of many chronic diseases including cardiovascular disease (CVD). While more current research has begun to focus
on the effects of specific polyphenol compounds found in fruits and vegetables, mechanistic insights have been hampered
by the multiple simultaneous effects these compounds may have on the disease process. In this article, we review the basic
research studies that have evaluated the effects of citrus flavonoids to: improve dyslipidemia, normalize glucose
homeostasis, prevent oxidative stress, and attenuate inflammation, which collectively have the ability to enhance
metabolic health and improve CVD risk.
Keywords: ApoB, atherosclerosis, cardiovascular disease, flavonoids, hesperitin, insulin resistance, naringenin, nobiletin,
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