Partial Protection of SHIV-Infected Chinese Rhesus Macaques Against Super-Infection with Heterologous SHIV Isolate

Author(s): Yue Li, Qiang Liu, Zhenwu Luo, Yanmeng Feng, Zhe Li, Qiang Wei, Yiming Shao.

Journal Name: Current HIV Research

Volume 10 , Issue 8 , 2012

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Background: Many studies have revealed a protective effect of infection with simian immunodeficiency virus (SIV) or simian-human immunodeficiency virus (SHIV) against subsequent infection by a related immunodeficiency virus. However, whether a protective response can be induced by an infection with an immunodeficiency virus is still currently debated in the HIV-1 vaccine field. The aim of this study was to evaluate the protection against SHIV challenge in Chinese macaques that had been inoculated with SHIVs containing different HIV-1 envelops.

Methods: Eleven adult Chinese rhesus monkeys were inoculated with SHIV-KB9, SHIV-1157ipd3N4 or SHIV-CN97001. After 30 weeks, the animals were exposed to SHIV-KB9 or SHIV-CN97001, which carried a heterologous envelope protein relative to the first challenge strain. Infection was monitored by measuring viral load and antibody response, as well as viral genome sequence analyses.

Results: After first challenge, all the monkeys demonstrated high viral loads and specific antibody responses. Protection from super-infection was statistically significant in all the animals inoculated with SHIV-KB9 or SHIV-1157ipd3N4. However, animals inoculated with SHIV-CN97001 and challenged with SHIV-KB9 showed new infections. The susceptibility to super-infection was not correlated with neutralizing antibodies present at the time of exposure to the second virus.

Conclusions: These findings indicate that different SHIV infection may confer different levels of protection against a second SHIV infection in Chinese monkeys. Understanding this protective response in SHIV infected macaques may shed a new light on HIV-1 vaccine development.

Keywords: SHIV, Chinese rhesus macaque, super-infection, protection, SHIV-KB9, SHIV-CN97001, CD4+, HIV, antibodies, 293T cells

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Article Details

Year: 2012
Page: [627 - 635]
Pages: 9
DOI: 10.2174/157016212803901446
Price: $65

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