A Practical Synthesis and X-ray Crystallographic Analysis of Dithymoquinone, a Photodimer of Thymoquinone | BenthamScience

A Practical Synthesis and X-ray Crystallographic Analysis of Dithymoquinone, a Photodimer of Thymoquinone

Author(s): Alan L. Myers, Yan-Ping Zhang, Mark A. Kramer, William G. Bornmann, Ahmed Kaseb, Peiying Yang, Hai T. Tran.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 10 , 2012

Abstract:

An updated and practical approach to the synthesis of dithymoquinone via one-step photoirradiation of thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone) is described. Synthesis resulted in a 55 % yield of one structural isomer (trans-anti derivative), as confirmed by HPLC, NMR spectroscopy and first ever single-crystal X-ray diffraction analyses.

Keywords: Dithymoquinone, photodimerization, thymoquinone, X-ray structure

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 9
ISSUE: 10
Year: 2012
Page: [762 - 766]
Pages: 5
DOI: 10.2174/157017812803901890

Article Metrics

PDF: 24