Hematoxylin as a General and Efficient Ligand for the Cu(I)-catalyzed S-arylation of Thiols with Aryl Halides in DMF-H2O

Author(s): Xiang-Mei Wu, Jian-Jun Mo.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 10 , 2012

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Abstract:

A combination of CuBr and hematoxylin was found to be a mild, efficient and environmentally benign catalyst system for S-arylation of thiols with aryl halides in DMF-H2O. A variety of aryl sulfides are synthesized from moderate to good yields, under relatively mild reaction conditions with good chemoselectivity and functional group tolerance.

Keywords: Aryl halide, aryl sulfide, copper, hematoxylin,

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Article Details

VOLUME: 9
ISSUE: 10
Year: 2012
Page: [749 - 755]
Pages: 7
DOI: 10.2174/157017812803901854
Price: $65

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