An Efficient Catalyst System for the Synthesis of N-(p-benzoylaminoaryl)- N'-Boc Piperazines Under Microwave Conditions

Author(s): Mule S. Reddy, Peruri V. V. Satyanarayana, Bollikolla Haribabu.

Journal Name:Letters in Organic Chemistry

Volume 9 , Issue 10 , 2012

Abstract:

We have developed a new combination of catalyst system for the synthesis of N-(p-benzoylaminoaryl)-N'-Boc piperazines under microwave conditions (Biotage, 300 Watt) in the presence of sodium tert-butoxide and in DMF. The catalyst and ligand used are Tris (dibenzylideneacetone) dipalladium(0) and 2-Dicyclohexylphosphino-2-(N,Ndimethylamino) biphenyl (Dave Phos) respectively, the desired N-(p-benzoylaminoaryl)-N'-Boc Piperazines was obtained in good yields (80-92%).

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Article Details

VOLUME: 9
ISSUE: 10
Year: 2012
Page: [739 - 744]
Pages: 6
DOI: 10.2174/157017812803901935
Price: $58