Calcium Channels and Prostate Cancer
George Shapovalov, Roman Skryma and Natalia Prevarskaya
Affiliation: Inserm U1003, USTL, F-59655 Villeneuve d’Ascq, France.
Calcium channels significantly contribute to many cellular processes, including such critical ones as proliferation,
differentiation, and apoptosis. In prostate cancer, the influence of calcium channels has been known for over 30
years, with the first observations that calcium channel blockers affect the progression of cancer towards more aggressive
phase. Later research identified additional classes of channel proteins having an important regulatory role and affecting
malignant transformation. This review discusses the accumulated scientific knowledge focused on calcium channel involvement
in regulation of cell fate in prostate tissues as well as recent developments in patents targeted at prostate cancer
treatments and involving calcium channel modulators.
Keywords: Apoptosis, calcium channels, cell fate, patent, proliferation, prostate cancer
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