Recent Progress on Fucosyltransferase Inhibitors

Author(s): Pedro Merino, Tomas Tejero, Ignacio Delso, Ramon Hurtado-Guerrero, Asier Gomez-SanJuan, David Sadaba.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 12 , Issue 14 , 2012

Become EABM
Become Reviewer

Abstract:

Fucosyltransferases (FucTs) are enzymes that transfer L-fucose from GDP-fucose to a glycoside or a peptide. They have important roles in a variety of diseases including cancer and autoimmune disorders, viral and bacterial infections and inflammatory processes, and thus they represent important drug targets for the development of agents for the treatment of such disorders. This review highlights recent developments regarding carbohydrate mimics as inhibitors of FucTs. The most recent and relevant synthetic strategies are described.

Keywords: Fucosyltransferases, Carbohydrate mimics, Glycoconjugates, Piperidines, Pyrrolidines, C-Glycosides, structure-activity-relationship, polyhydroxylated

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 12
ISSUE: 14
Year: 2012
Page: [1455 - 1464]
Pages: 10
DOI: 10.2174/138955712803832753
Price: $58

Article Metrics

PDF: 34